Quantification of intact ambroxol tablet using near-infrared spectroscopy

  • Published : 2003.04.01

Abstract

NIR reflectance spectroscopy, using a fiber-optic probe was used to determine rapidly and non-destructively the content of ambroxol in intact ambroxol 30 mg (nominal content 12.5% m/m ambroxol) tablets by collecting NIR spectra in range 1100 - 1750 nm and using PLSR calibration method. The tablets (10.3 - 15.9% m/m ambroxol, i.e., 82 - 127% of the nominal label content) were used 7 calibration set and 5 validation set. (omitted)

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