대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.268.1-268.1
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- 2003
The Mechanism of DNA Strand Scissions Induced by Brazilin : Involvement of Reactive Oxygen Species and Cu(II)/Cu(I) Redox Cycling
- Lee, Sun-Young (Dept. of Biochemistry, Yeungnam University) ;
- Kim, Tae-Ho (Dept. of Biochemistry, Yeungnam University) ;
- Kim, Seog K. (Dept. of Chemistry, Yeungnam University) ;
- Mar, Woong-Chon (Natural Products Research Institute, Seoul National University) ;
- Seo, Eun-Kyoung (College of Pharmacy, Ewha Womans University) ;
- Lee, Chong-Soon (Dept. of Biochemistry, Yeungnam University)
- 발행 : 2003.04.01
초록
Brazilin is the phenolic compound isolated from the Caesalpinia sappan. This compound has shown a wide range of physiological properties, such as hypoglycemic, anticonvulsant, vasorelaxing, and immunomodulating effects. In this study, we have found that brazilin induced DNA strand scissions in the presence of Cu(II) and this DNA cleavages were mediated by reactive oxygen species. (omitted)
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