Prenylated Flavonoids, Inhibitors of Diacylglycerol Acyltransferase by the root of Sophora flavescens

Diacylglycerol acyltransferase (DGAT) is a microsomal enzyme that plays a central role in the metabolism of cellular glycerolipid. Recently, the generation of DGA T-deficient mice has provided a better understanding of triglyceride synthesis and its relationship to obesity. Therefore DGAT is an attractive target for treatments of triglyceride metabolism disorders, such as obesity or hypertriglyceridemia. (omitted)