Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.265.2-265.2
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- 2003
Inhibitory activity of diarylheptanoids on farnesyl protein transferase
- Kang, Hyun-Mi (Korea Research Institute of Bioscience and Biotechnology) ;
- Jeon, Sun-Bok (School of Life Sciences, College of Natural Sciences, Chungbuk National University) ;
- Son, Kwang-Hee (School of Life Sciences, College of Natural Sciences, Chungbuk National University) ;
- Yang, Deok-Cho (School of Life Sciences, College of Natural Sciences, Chungbuk National University) ;
- Han, Dong-Cho (School of Life Sciences, College of Natural Sciences, Chungbuk National University) ;
- Kwon, Byoung-Mog (School of Life Sciences, College of Natural Sciences, Chungbuk National University)
- Published : 2003.04.01
Abstract
Diarylheptanoids [curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), bisdimethoxymethylcurcumin (4), and 1,2-dihydrobis(de-O-methyl)curcumin (5)] were isolated from the methanolic extract of Curcuma longa L. and A new cyclic diarylheptanoiid (6) and a known compound 7 were isolated from fruits of Alnus japonica S. Diarylheptanoids (1-3) inhibited farnesyl protein transferase (FTPase) with an IC50 of 29-50
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