Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Aldose Reductase Inhibitory Constituents from Ganoderma applanatum

  • Shim, Sang-Hee (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Ryu, Ji-Young (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kim, Ju-Sun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Chung, Sang-Hun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Lee, Yeon-Sil (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Lee, Sang-Hyun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute and College of Pharmacy, Seoul National University)
  • Published : 2003.04.01
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Abstract

The EtOAc and CH$_2$Cl$_2$ soluble fractions from the fruit body of Ganoderma applanatum showed strong aldose reductase inhibitory activity. Nine compounds were isolated from both fractions. They were identified by spectral data as D-mannitol (1), 2-methoxyfatty acid (2), cerebrosides [(2S,3R,4E,8E)-1-O-${\beta}$-D-glucopyranosyl-3-hydroxy-2-[(R)-2'-hydroxypalmitoyl]amino-9-methyl-4,8-octadecadiene] (3), daucosterol (4), 2,5-dihydroxybenzoic acid (5), protocatechualdehyde (6), 5-dihydroergosterol (7), ergosterol peroxide (8), and cerevisterol (9). (omitted)

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