Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.250.1-250.1
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- 2003
CoMFA and CoMSIA 3D QSAR Studies on Pimarane Cyclooxygenase-2 (COX-2) Inhibitors
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Suh, Young-Ger
(College of Pharmacy, Seoul National University)
;
- Lee, Kwang-Ok (College of Pharmacy, Sungkyunkwan University) ;
- Park, Hyun-Ju (College of Pharmacy, Chungnam University) ;
- Kim, Young-Ho (College of Pharmacy, Chungnam University) ;
- Moon, Sung-Hyun (College of Pharmacy, Chungnam University)
- Published : 2003.04.01
Abstract
In this work, we have conducted 3D-QSAR studies on a series of acanthonic acid derivatives that act as COX-2 inhibitors, using two different methods: comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). CoMFA and CoMSIA analysis of twenty five pimarane analogues produced good models with high predictive abilities. (omitted)
Keywords