Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Structure-activity Relationship Study of Fluoro-Neplanocin A as Potential Antiviral and Antitumor Agents

  • Shin, Dae-Hong (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Moon, Hyung-Ryong (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Choi, Won-Jun (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Lee, Kang-Man (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Lee, Sang-Kook (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Jeong, Lak-Shin (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University)
  • Published : 2003.04.01
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Abstract

S-Adenosylhomocysteine hydrolase (SAH) catalyzes the hydrolysis of S-adenosylhomocysteine to adenosine and L-homocysteine and has been an attractive target for the development of broad spectrum antiviral agents. Based on the potent inhibitory activity of neplanocin A against SAH, we have reported the synthesis and novel mechanism of action of fluoro-neplanocin A. (omitted)

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