Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.238.3-239
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- 2003
Stereoselective synthesis of carbocyclic analogue of Nucleocidin
- Kim, Ji-Hee (College of Pharmacy, Chosun University) ;
- Quan, Ying-Lin (College of Pharmacy, Chosun University) ;
- Ko, Ok-Hyun (College of Pharmacy, Chosun University) ;
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Hong, Joon-Hee
(College of Pharmacy, Chosun University)
- Published : 2003.04.01
Abstract
Among 4'-substituted nucleosides. Nucleocidin. 4'-azido thymidine (ADRT), 4'-fluorinated carbocyclic nucleoside. and 3'-fluoro oxetanosin analogue have demonstrated a variety of biological activities. Since the cyclopentane ring of carbocyclic nucleosides can emulate the furanose moiety. a number of these compounds exhibit interesting biological activity, particularly in the areas of antiviral and anticancer chemotherapy. (omitted)
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