Synthesis and Biological Activity of 1$\beta$-Methyl-2-[5-(2-N-Substituted aminoethylcarbamoyl)pyrrolidin-3-ylthio]carbapenem Derivatives.

The synthesis of a new series of 1${\beta}$-methylcarbapenems having the substituted aminoethyl-carbamoylpyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. In particular. the compound 11 g having piperazinyl urea moiety showed the most potent antibacterial activity.