Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.235.3-236
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- 2003
A synthesis of sugar-modified S-adenosyl-L-homocysteine(AdoHcy) analogues as inhibitors of AdoHcy hydrolase via the coupling sugar-modified adenosine analogues with L-homocysteine sodium salt.
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Kim, Beom-Tae
(Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University)
;
- Kim, Seung-Ki (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University) ;
- Ryu, Jeong-Hyun (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University) ;
- Hwang, Ki-Jun (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University)
- Published : 2003.04.01
Abstract
S-adenosyl-L-homocysteine(AdoHcy) is the product of all biological methylation in which S-adenosyl-L-methionine (AdoMet) is utilized as a methyl donor and is reversibly hydrolyzed to L-homocysteine and adenosine by AdoHcy hydrolase physiologically. Inhibition of this enzyme results in intracelluar accumulation of AdoHcy leading to a feedback inhibition of AdoMet-dependent methylation reactions which are essential for viral replication. (omitted)
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