Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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C2-phytoceramide and Dimethylphytosphingosine induces cell death and apoptosis in human breast cancer cells, MDA-MB-231

  • Kim, Yun-Wha (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, KAERI) ;
  • Jeon, Soo-Jin (Doosan Biotec) ;
  • Kim, Ki-Sung (Department of Applied Chemistry, Dongduk Women′s University) ;
  • Han, Young-Soo (Department of Applied Chemistry, Dongduk Women′s University) ;
  • Song, Jie-Young (Department of Applied Chemistry, Dongduk Women′s University) ;
  • Park, Chang-Seo (Department of Applied Chemistry, Dongduk Women′s University) ;
  • Jung, In-Sung (Department of Applied Chemistry, Dongduk Women′s University) ;
  • Hong, Sung-Hee (Department of Applied Chemistry, Dongduk Women′s University) ;
  • Yun, Yeon-Sook (Department of Applied Chemistry, Dongduk Women′s University)
  • Published : 2003.04.01
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Abstract

Sphingolipid metabolites have been implicated as an important component of cell signalling, such as cell proliferation, differentiation and apoptosis. But the roles of phytoceramide and its deraivatives are very poorly understood. even though they are abundant in plants, yeasts and animals including humans. We investigated the effects of N-acetyl-C2-phytosphingosine(NAPS) and the analogue of N.N-dimethylsphingosine(DMS), N,N-dimethylphytosphytosphingosine(DMPS), on cell growth inhibition and apoptosis. (omitted)

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