Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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A Liquid Culture Bioassay System for the Detection of Quorum Sensing Signaling AHL Analogues

  • Kim, Young-Hee (Department of Biotechnology, Dongseo University ＆ Department of Chemical Engineering, Pusan National University) ;
  • Lee, Jae-Geun (Department of Biotechnology, Dongseo University ＆ Department of Chemical Engineering, Pusan National University) ;
  • Park, Sung-Hoon (Department of Biotechnology, Dongseo University ＆ Department of Chemical Engineering, Pusan National University) ;
  • Kim, Jung-Sun (Department of Biotechnology, Dongseo University ＆ Department of Chemical Engineering, Pusan National University)
  • Published : 2003.04.01
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Abstract

Recent studies have revealed that bacterial biofilm production by the gram-negative bacteria is regulated by the quorum sensing signaling molecules, AHLs (N-acyl homoserine lactones). This suggests that inhibiting the AHLs could enhance the effects of antibacterial agents. Halogenated furanones purified from the red algae Delisea pulchra have been known to decrease quorum sensing responses by competitive inhibition of the AHLs. (omitted)

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