Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Correlation between signal pathway of chitosan and nitric oxide

  • Yoon, Hyun-Joong (College of Pharmacy, Chonnam National University) ;
  • Kim, Young-Ho (College of Natural science, Department of biology, Chosun National University) ;
  • Park, Haeng-Soon (College of Pharmacy, Chonnam National University)
  • Published : 2003.04.01
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Abstract

Renal dipeptidase (RDPase, EC 3.4.13.19), an ectoenzyme of renal proximal tubules, is covalently bound to outer leaflet of lipid bilayer via glycosylphosphatidylinositol (GPI)-anchor. Chitin is a major component of the shells of crustacea such as crab, shrimp and crawfish. This study was conducted to examine the effect of chitosan on RDPase release from renal proximal tubules. Nitric oxide (NO), highly reactive free radical, inhibits the release of RDPase from porcine proximal tubules. (omitted)

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