Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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PROTECTION OF PARAOXONASE BY LIPIDS

  • Su, Nguyen-Duy (College of Pharmacy, Chungnam National University) ;
  • Kim, Ju-Ruyng (College of Pharmacy, Chungnam National University) ;
  • Sok, Dai-Eun (College of Pharmacy, Chungnam National University)
  • Published : 2003.04.01
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Abstract

Effect of lipids on the oxidative inactivation of paraoxonasel (PON1), a HDL -associated antioxidant protein, was investigated, based on the hydrolysis of phenyl acetate. First. various fatty acids were examined for the prevention against the inactivation of PON1 byascorbate/Cu2+ system, which caused a remarkable ($\geq$ 90％) inactivation of PON1, accompanied by a partial loss of histidine residues. (omitted)

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