Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Suppressoin of NF-$_k$B signaling pathways by ergolide in HeLa cells

  • Yoon, Jong-Woo (Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University) ;
  • Chun, Jae-Kwang (Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University) ;
  • Cho, Eun-Jung (Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University) ;
  • Han, Jeung-Whan (Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University) ;
  • Lee, Hyang-Woo (Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University)
  • Published : 2003.04.01
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Abstract

In previous study, we investigated the mechanism of suppression of inducible nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2) by ergolide, sesquiterpene lactone from Inula Britannica. In this study, the suppression of iNOS and COX-2 by ergolide might be attributed to selective inhibition of NF-$\_$K/B signaling pathways. Here, we investigated the suppressionmechanism of NF-$\_$K/B signaling pathways by ergolide in TPA-stimulated HeLa cells. (omitted)

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