Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Anticoagulant Activity of Acharan Sulfate In Vivo

  • Li, Da-Wei (Natural Products Research Institute, College of Pharmacy Seoul National University) ;
  • Choi, Hyung-Seok (Natural Products Research Institute, College of Pharmacy Seoul National University) ;
  • Lee, In-Sun (Natural Products Research Institute, College of Pharmacy Seoul National University) ;
  • Toida, Toshihiko (Graduate School of Pharmaceutical Sciences, Chiba University) ;
  • Kim, Yeong-Shik (Natural Products Research Institute, College of Pharmacy Seoul National University)
  • Published : 2003.04.01
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Abstract

We previously reported that acharan sulfate from the African giant snail Achatina futica showed the anticoagulant activity in vitro, but it was much less than that of heparin. In present study, the anticoagulant activity of acharan sulfate was investigated in vivo. Intravenous administration of acharan sulfate prolonged the clotting time (APTT) in mice and rats in a dose-dependent manner. (omitted)

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