Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.214.1-214.1
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- 2003
Inhibition of lipopolysaccharide-induced inflammatory mediators NO, PGs, TNF-$\alpha$ expression by MeOH extract of Kochia scoparia in RAW264.7 cells.
- Shin, Kyung-Min (Biochemistry Lab. College of Pharmacy, Kyunghee unv.) ;
- Kim, Yang-Hee (Biochemistry Lab. College of Pharmacy, Kyunghee unv) ;
- Park, Wan-Soo (Biochemistry Lab. College of Pharmacy, Kyunghee unv) ;
- Lee, Kyung-Tae (Biochemistry Lab. College of Pharmacy, Kyunghee unv) ;
- Park, Hee-Jun (Biochemistry Lab. College of Pharmacy, Kyunghee unv) ;
- Choi, Jung-Won (Biochemistry Lab. College of Pharmacy, Kyunghee unv.)
- Published : 2003.04.01
Abstract
MeOH extract obtained from the Kochia scoparia (KS) was observed to inhibit tumor necrosis factor-alpha (TNF-alpha), prostaglandins (PGs) and nitric oxide(NO) production in a lipopolysaccharide (LPS)-stimulated murine macrophage cell line, RAW 264.7. These effects of MeOH-KS were based on modulation of iNOS and COX-2 level. Western blot analysis showed that MeOH-KS reduced the iNOS and COX-2 level in LPS activated macrophages, in a dose dependent manner without cNOS and COX-1 protein level. (omitted)
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