Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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15-Deoxy-$PGJ_2$ Stimulates Neuronal Differentiation of Embryonic Midbrain Cells by Up-regulation of PPAR-gamma Activity via the JNK-dependent Pathway

  • Park, Ki-Sook (College of Pharmacy, Chungbuk National University) ;
  • Lee, Sang-Min (College of Pharmacy, Chungbuk National University) ;
  • Lee, Rhee-Da (College of Pharmacy, Chungbuk National University) ;
  • Han, Soon-Young (College of Pharmacy, Chungbuk National University) ;
  • Park, Kui-Lae (College of Pharmacy, Chungbuk National University) ;
  • Yang, Ki-Hwa (College of Pharmacy, Chungbuk National University) ;
  • Song, Yuen-Sook (College of Pharmacy, Chungbuk National University) ;
  • Moon, Dong-Chuel (College of Pharmacy, Chungbuk National University) ;
  • Song, Suk-Gil (College of Pharmacy, Chungbuk National University)
  • Published : 2003.04.01
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Abstract

The effect of 15-deoxy-PGJ$_2$ on the differentiation of embryonic midbrain cells into dopaminergic neuronal cells, and the relationship between cell differentiation with activation of PPAR-yand possible signal pathway were investigated, 15-Deoxy-PGJ$_2$ increased neurite extension, a typical characteristics of the differentiation of embryonic midbrain cells isolated from 12 day's rat embryos in a dose-dependent manner. (omitted)

Keywords