Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Overexpression of Bcl-2 protects differentiated PC12 cells against beta amyloid- induced apoptosis through inhibition of NF-kB and p38 MAP kinase activation

  • Song, Youn-Sook (College of Phanrmacy, Chungbuk National University) ;
  • Park, Hye-Ji (College of Phanrmacy, Chungbuk National University) ;
  • Hwang, In-Young (College of Phanrmacy, Chungbuk National University) ;
  • Lee, Sun-Young (College of Phanrmacy, Chungbuk National University) ;
  • Yun, Yeo-Pyo (College of Phanrmacy, Chungbuk National University) ;
  • Lee, Myung-Koo (College of Phanrmacy, Chungbuk National University) ;
  • Oh, Ki-Wan (College of Phanrmacy, Chungbuk National University) ;
  • Hong, Jin-Tae (College of Phanrmacy, Chungbuk National University)
  • Published : 2003.04.01
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Abstract

Activation of the apoptosis program by an increased production of beta-amyloid peptides (A${\beta}$) has been implicated in the neuronal cell death of Alzheimer's disease. Bcl-2 is a well demonstrated anti-apoptotic protein, however, the mechanism of anti-apoptotic action of Bcl-2 in A${\beta}$-induced apoptosis of neuronal cells is not fully understood. (omitted)

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