Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.192.1-192.1
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- 2003
Histamine Signaling Pathway in Sensory Neurons is Similar to Bradykinin
- Lee, Sang-Hee (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
- Koo, Jae-Yeon (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
- Kim, Sang-Sung (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
- Lee, Jung-Youn (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
- Cho, Ha-Won (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
- Kim, Byung-Moon (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University) ;
- Oh, Uh-Taek (The Sensory Research Center, Creative Research Initiatives, College of Pharmacy, Seoul National University)
- Published : 2003.04.01
Abstract
Histamine is found in most tissues of the body and activates polymodal nociceptors via unmyelinated afferent C-fibres. We have demonstrated that bradykinin. acting at B2 bradykinin receptors. excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid in dorsal root ganglion. Histamine is known to the activator of phospholipase A2- arachidonic acid pathway via a G-protein- coupled H1 receptor. (omitted)
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