Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.185.2-185.2
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- 2003
Effects of Dially Sulfide on Thioacetamide-induced Hepatotoxicity
- Hyun, Sun-Hee (College of Food Technology, Yeungnam University) ;
- Kim, Nam-Hee (College of Pharmacy, Yeungnam University) ;
- Kim, Chun-Hwa (College of Pharmacy, Yeungnam University) ;
- Lee, Sang-Kyu (College of Pharmacy, Yeungnam University) ;
- Lee, Dong-Wook (College of Pharmacy, Yeungnam University) ;
- Jeon, Tae-Won (College of Pharmacy, Yeungnam University) ;
- Lee, Jae-Sung (College of Food Technology, Yeungnam University) ;
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Jeong, Tae-Cheon
(College of Pharmacy, Yeungnam University)
- Published : 2003.04.01
Abstract
Effects of diallyl sulfide (DAS), a component of garlic, on thioacetamide-induced hepatotoxicity were investigated in male ICR mice. When mice treated subcutaneously with 100, 200 and 400 mg/kg of DAS in corn oil for three consecutive days, the activity of cytochrome P450 (P450) 2E1-selective p-nitrophenol hydroxylase was dose-dependently suppressed. In addition, the activities of P450 2B-selective benzyloxyresorufin O-debenzylase and pentoxyresorufin O-depentylase were dose-dependently induced by the treatment with DAS. (omitted)
Keywords