Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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The Inhibitory Effect of Zinc on the Cadmium-Induced Apoptosis in Human Breast Cancer Cells

  • Oh, Ji-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA) ;
  • Lee, Su-Jung (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Shin, Jae-Ho (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kim, Tae-Sung (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Moon, Hyun-Ju (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kang, Il-Hyun (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kim, In-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, KFD) ;
  • Kim, An-Keun (College of Pharmacy, SookMyung Women′s University) ;
  • Han, Soon-Young (Endocrine Toxicology Division, National Institute of Toxicological Research, KFDA)
  • Published : 2003.04.01
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Abstract

Zinc is known to have an inhibitory effect on apoptosis and an antioxidative effect scavenging reactive oxygen species (ROS) under oxidative stress. We studied the influence of zinc on cadmium-induced apoptosis especially associated with ROS in MCF-7 human breast carcinoma cell line. For the determination of appropriate experimental concentration and time, we excecuted MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] assay and DNA fragmentation assay. (omitted)

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