Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Inhibition of capsaicin on pulmonary metastasis of 816-F10 melanoma cells

  • Kim, Ok-Hee (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jun, Hye-Seung (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Park, Mi-Sun (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Eom, Mi-Ok (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Jee, Seung-Wan (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Ryeom, Tai-Kyung (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Kang, Ho-Il (National Institute of Toxicological Research, Korea Food and Drug Administration)
  • Published : 2003.04.01
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Abstract

Capsaicin (8-methyl-N-vanillyl-6-nonenamide), a pungent ingredient of hot chili peppers, has been reported to possess substantial anticarcinogenic and antimutagenic activities. In the present study. we investigated the effects of capsaicin on pulmonary metastasis of B 16-F10 murine melanoma cells. as well as its mechanism of action. Capsaicin (i.p.. 2.5mg/kg) suppressed the number of lung colonies (58％) in experimental lung metastasis assay. (omitted)

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