Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.177.1-177.1
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- 2003
Genotoxicity Study of sophoricoside in bacterial and mammalian cells system
- Yun, Hye-Jung (Toxicology Laboratory, Korea Institute of Science ＆ Technology) ;
- Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science ＆ Technolog) ;
- Kim, Eun-Young (Toxicology Laboratory, Korea Institute of Science ＆ Technolog) ;
- Kim, Young-Soo (College of Pharmacy, Chungbuk Natl. Univ) ;
- Kim, Mi-Kyung (College of Medicine, Chungbuk Natl. Univ) ;
- Lee, Seung-Ho (College of Pharmacy, Yeungnam Univ) ;
- Jung, Sang-Hun (College of Pharmacy, Chungnam Natl. Univ) ;
- Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science ＆ Technology)
- Published : 2003.04.01
Abstract
Sophoricoside was isolated as the inhibitor of IL -5 bioactivity from Sophora japonica (Leguminosae). It has been reported to have an anti-inflammatory effect on rat paw edema model. To develope as an anti-allergic drug, genotoxicity of sophoricoside was investigated in bacterial and mammalian cell system such as Ames bacterial test and mouse lymphoma tk gene assay (MOLY). (omitted)
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