Platycodi Radix inhibits endothelial cell invasion and angiogenesis

  • Shin, Dong-Weon (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
  • Lee, Kyung-Jin (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
  • Jeong, Hye-Gwang (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University)
  • Published : 2003.04.01

Abstract

Herbal medicines are increasingly being utilized to treat a wide variety of disease processes. In this study, we assayed the preventive and therapeutic effects of aqueous extract from the roots of Platycodon grandilflorum. A DC, Changil (CK) in human microvessel endothelial cell-1 (HMEC-1) angiogenesis. CK inhibited cell migration and in the presence of CK proliferation of HMEC-1 was inhibited in a dose-dependent manner. (omitted)

Keywords