대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.164.2-165
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- 2003
Inorganic Arsenic Increases Vasoconstriction through Calcium-Sensitization in Vascular Smooth Muscles
- Lee, M.Y. (College of Pharmacy, Seoul National University) ;
- Lee, Y.H. (College of Medicine, Yonsei University) ;
- Bae, O.K. (College of Pharmacy, Seoul National University) ;
- Chung, J.H. (College of Pharmacy, Seoul National University)
- 발행 : 2003.04.01
초록
Chronic exposure of arsenic is well known to be the cause of cardiovascular disease such as hypertension. In order to investigate the effect of arsenic on blood vessels. we examined whether arsenic affected agonist-induced contraction of aortic rings in isolated organ bath system. Treatment with arsenite increased vasoconstriction induced by phenylephrine or serotonin in a concentration-dependent manner. (omitted)
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