Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Effect of Arsenic on Acetylcholine-Induced Relaxation in Blood Vessels

  • Lee, M.Y. (College of Pharmacy, Seoul National University) ;
  • Chung, S.M. (College of Pharmacy, Seoul National University) ;
  • Bae, O.N. (College of Pharmacy, Seoul National University) ;
  • Chung, J.H. (College of Pharmacy, Seoul National University)
  • Published : 2003.04.01
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Abstract

Several epidemiological studies suggested that arsenic exposure was strongly correlated with the development of cardiovascular disease such as hypertension. In order to examine whether arsenic affects vasomotor tone in blood vessels, we investigated the effect of arsenic on agonist-induced vasorelaxation using the isolated rat aortic rings in vitro organ bath system.Treatment with arsenite inhibited acetylcholine-induced relaxation of aortic rings in a concentration-dependent manner. (omitted)

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