Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.162.2-163
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- 2003
The altered sphingolipid metabolism in rats following fumonisin B1 exposure
- Choi, Heon-Kyo (College of Pharmacy, Chungbuk National University) ;
- Yoo, Jae-Myung (College of Medicine, Ewha Woman) ;
- Oh, Sei-Kwan (College of Medicine, Ewha Woman) ;
- Lee, Yong-Moon (College of Medicine, Ewha Woman) ;
- Yun, Yeo-Pyo (College of Medicine, Ewha Woman) ;
- Yoo, Hwan-Soo (College of Medicine, Ewha Womans)
- Published : 2003.04.01
Abstract
Fumonisins are specific inhibitors of ceramide synthase in sphingolipid metabolism. The objective of this study was to investigate whether the elevation of free sphingoid bases 1-phosphate (S1P) are related to the fumonisin exposure. Sprague Dawley rats were injected i.p. with 10mg/kg fumonisin B1 (FB1), and kidney, liver, heart, lung, brain and serum were collected for sphingolipid analysis. (omitted)
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