대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Induction of Quinone Reductase by Obtusafuran from Dalbergiae Lignum

  • Yin, Hu-Quan (College of Pharmacy and Medicinal Resources Research center, Wonkwang University) ;
  • Oh, Seon-Hee (College of Pharmacy and Medicinal Resources Research center, Wonkwang University) ;
  • Kim, Youn-Chul (College of Pharmacy and Medicinal Resources Research center, Wonkwang University) ;
  • Sohn, Dong-Hwan (College of Pharmacy and Medicinal Resources Research center, Wonkwang University) ;
  • Lee, Byung-Hoon (College of Pharmacy and Medicinal Resources Research center, Wonkwang University)
  • 발행 : 2003.04.01
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초록

NAD(P)H:quinone oxidoreductase (quinone reductase: QR: EC1.6.99.2), a cytosolic FAD-containing flavoprotein, form one of the important component of the phase II drug-metabolizing enzyme systems. It is found in all mammalian species tested and is expressed in many organs including the liver. QR catalyses two-electron reduction of qui nones to hydroquinones thereby suppresses the formation of superoxide anion radical. (omitted)

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