Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.161.1-161.1
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- 2003
Induction of Quinone Reductase by Obtusafuran from Dalbergiae Lignum
- Yin, Hu-Quan (College of Pharmacy and Medicinal Resources Research center, Wonkwang University) ;
- Oh, Seon-Hee (College of Pharmacy and Medicinal Resources Research center, Wonkwang University) ;
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Kim, Youn-Chul
(College of Pharmacy and Medicinal Resources Research center, Wonkwang University)
;
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Sohn, Dong-Hwan
(College of Pharmacy and Medicinal Resources Research center, Wonkwang University)
;
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Lee, Byung-Hoon
(College of Pharmacy and Medicinal Resources Research center, Wonkwang University)
- Published : 2003.04.01
Abstract
NAD(P)H:quinone oxidoreductase (quinone reductase: QR: EC1.6.99.2), a cytosolic FAD-containing flavoprotein, form one of the important component of the phase II drug-metabolizing enzyme systems. It is found in all mammalian species tested and is expressed in many organs including the liver. QR catalyses two-electron reduction of qui nones to hydroquinones thereby suppresses the formation of superoxide anion radical. (omitted)
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