Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.154.2-155
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- 2003
DW1350, a Newly Synthetic Anti-osteoporotic Agent: 1. DW-1350 Inhibited Bone Resorption and Promoted Bone Formation
- Lee, Jin-Soo (Central Research Laboratories, Dong-Wha Pharm. Ind. Co., Ltd) ;
- Whang, Yun-Ha (Central Research Laboratories, Dong-Wha Pharm. Ind. Co., Ltd, Biochemistry Department, Seoul National University) ;
- Ahn, Seok-Hoon (Central Research Laboratories, Dong-Wha Pharm. Ind. Co., Lt) ;
- PanSoo (Central Research Laboratories, Dong-Wha Pharm. Ind. Co., Lt) ;
- Jin, Sang-Mi (Central Research Laboratories, Dong-Wha Pharm. Ind. Co., Lt) ;
- Yi, Sun-Shin (Central Research Laboratories, Dong-Wha Pharm. Ind. Co., Lt) ;
- Jung, Young-Ho (Central Research Laboratories, Dong-Wha Pharm. Ind. Co., Lt) ;
- Suh, Hong-Suk (Department of Chemistry, Pusan National University) ;
- Ryu, Jei-Man (Central Research Laboratories, Dong-Wha Pharm. Ind. Co., Ltd)
- Published : 2003.04.01
Abstract
Recently, we developed a new anti-osteoporotic agent, DW-1350, which not only inhibited osteoclast formation but also induced osteoblast differentiation through the in vitro randomized screening studies. We identified inhibitory activities of DW-1350 for each step of osteoclast differentiation, fusion and pit formation process in co-culture system with mouse bone marrow and primary osteoblasts. (omitted)
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