Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.148.1-148.1
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- 2003
Neuroprotective Effect of Polygae Radix on the Brain Ischemia Induced by Four- Vessel Occlusion in Rats
- Kim, Young-Ock (Jaseng Research Institute of Bio- Technology and Bioscience) ;
- Lee, Hyun-Sun (Dept. of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University) ;
- Lee, Young-Ah (Dept. of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University) ;
- Shin, Joon-Shik (Dept. of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University) ;
- An, Deuk-Kyun (Dept. of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University) ;
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Kim, Ho-Chol
(Dept. of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University)
- Published : 2003.04.01
Abstract
The effects of methanolic extracts of Polygalae Radix (PR 100mg/kg) was tested to evaluate on the neuroprotective activity (92％ p<0.001) on global cerebral schemia. Based on bioassays guided fractionation, butanol soluble fraction (BtOH 25mg/kg) had the neuroprotive effect (87％ p<0.001) of global cerebral ischemia in rat. Oxygen free radical injury plays an important role in neuronal damage induced by brain ischemia and reperfusion. (omitted)
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