Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory effects of berberine on morphine-induced behavioral sensitization in mice

  • Yang, Eun-Mi (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Kim, Kyung-In (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Yoo, Ji-Hoon (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Lee, Seok-Yong (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Jang, Choon-Gon (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University)
  • Published : 2003.04.01
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Abstract

The present study was investigated the effect of berberine on the development of behavioral sensitization by morphine, methampethamine, and cocaine. Repeated administration of morphine (10 mg/kg), methampethamine (2 mg/kg), and cocaine (15 mg/kg) produced behavioral sensitization in mice. Pretreatment with berberine (2 mg/kg) did not inhibit methampethamine-and cocaine-induced behavioral sensitization. (omitted)

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