Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory Effects on Dopamine Biosynthsis and Protective Effect on L-DOPA-induced Neurotoxicity of liriodenine in PC12 cells

  • Jin, Chun-Mei (College of Pharmacy, and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Lee, Jae-Joon (Korea Research Institute of Chemical Technology) ;
  • Yin, Shou-Yu (Korea Research Institute of Chemical Technolog) ;
  • Kim, Yu-Mi (Korea Research Institute of Chemical Technolog) ;
  • Yang, You-Jong (Korea Research Institute of Chemical Technolog) ;
  • Ryu, Si-Yong (Korea Research Institute of Chemical Technolog) ;
  • Lee, Myung-Koo (Korea Research Institute of Chemical Technology)
  • Published : 2003.04.01
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Abstract

The effects of liriodenine, an aporphine isoquinoline alkaloid, on dopamine biosynthesis and L-DOPA-induced neurotoxicity in PC12 cells were investigated. Treatment of PC12 cells with liriodenine at 10 $\mu\textrm{M}$ showed 33.6％ inhibition of dopamine content decreased at 3 h and reached a minimal level at 12 h after the exposure to liriodenine at 10 $\mu\textrm{M}$. (omitted)

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