Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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In vivo metabolism of 2-methylaminoethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylenedioxybiphenyl-2′-carboxy-2-carboxylate (DDB-S) in rats using deutrium labeled compound

  • Lee, Eun-Young (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Shin, Myoung-Youp (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technolog) ;
  • Lee, Mi-Jin (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technolog) ;
  • Jung, Ha-Youn (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technolog) ;
  • Son, Jung-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technolog) ;
  • Kim, Dong-Hyun (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
  • Published : 2003.04.01
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Abstract

2-Methylaminoethyl-4, 4'-dimethoxy-5, 5', 6.6 -dimethylenedioxybiphenyl-2'-carboxy-2-carboxylate (DDB-S), a synthetic compound derived from DDB, has been known to protect liver against carbon tetrachloride-, D-galactosamine-, thioacetamide-, and prednisolone-induced hepatic injury in experimental animals. The metabolism of this compound has been assessed in rats by using liquid chromatography/electrospray tandem mass spectrometry (LC/MS/MS) method. (omitted)

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