Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Antitumor activity and 3D-Histoculture drug response assay of Novel trans- ditrifluoroacetato,malonato-1,4-butanediamine Pt(IV) complex, K104

  • Kwon, Young-Ee (Drug Discovery Institute, STC Life Science Center, College of Pharmacy Dongduk Women′s University) ;
  • Kim, Kuk-Hwan (Drug Discovery Institute, STC Life Science Center, College of Pharmacy Dongduk Women′s University) ;
  • Oh, Bong-Un (Drug Discovery Institute, STC Life Science Center, College of Pharmacy Dongduk Women′s University) ;
  • Kim, Kap-Joon (Drug Discovery Institute, STC Life Science Center, College of Pharmacy Dongduk Women′s University)
  • Published : 2003.04.01
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Abstract

Novel trans-ditrifluoroacetato, malonato-1, 4-butanediamine Pt(IV) complex, K104 was synthesized as a chemotherpeutic. The cytotoxicity of K104 against various human cancer cell lines were evaluated by MTS assay in vitro. The IC50 values of K104 ranged 15.83-25.83 $\mu\textrm{M}$, compared to CBCDA ranged 23.24-69.6 $\mu\textrm{M}$. Among several cancer cell lines, K104 showed more potent than CBCDA in colon cancer cell lines. (omitted)

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