Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Attenuation of nicotine-induced locomotor sensitization in $\mu$-opioid receptor knockout mice

  • Yoo, Ji-Hoon (Department of Pharmacology. College of Pharmacy, Sungkyunkwan University) ;
  • Yang, Eun-Mi (Department of Pharmacology. College of Pharmacy, Sungkyunkwan University) ;
  • Kim, Kyung-In (Department of Pharmacology. College of Pharmacy, Sungkyunkwan University) ;
  • Lee, Seok-Yong (Department of Pharmacology. College of Pharmacy, Sungkyunkwan University) ;
  • Jang, Choon-Gon (Department of Pharmacology. College of Pharmacy, Sungkyunkwan University)
  • Published : 2003.04.01
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Abstract

The present study was undertaken to examine the hypothesis that $\mu$-opioid receptors play a crucial role in behavioral sensitization to nicotine using $\mu$-opioid receptor knockout mice. All mice were treated acutely or repeatedly with nicotine 0.05 mg/kg twice daily for 7 consecutive days. The mice were challenged with nicotine on day 11. And locomotor activity was measured for 30min. (omitted)

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