Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.126.2-127
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- 2003
An antiarrhythmic drug for atrial fibrillation from Chelidonium majus
- Eun, Jae-Soon (College of Pharmacy, Woosuk University) ;
- Kim, Dae-Keun (College of Pharmacy, Woosuk University) ;
- Kwak, Yong-Geun (Chonbuk National University Medical School)
- Published : 2003.04.01
Abstract
The therapeutic potential of currently available antiarrhythmic drugs is limited by their tendency to induce proarrhythmic and extracardiac side effects. An ideal antiarrhythmic agent would selectively prolong the action potential duration more in extraordinarily depolarized cardiac myocytes than in normal cells. and show tissue selectivity. Voltage-gated K+ (Kv) channels represent a structurally and functionally diverse group of membrane proteins. (omitted)
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