Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.125.2-126
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- 2003
High Throughput Fluorogenic Assay for TNF-alpha Converting Enzyme(TACE) inhibitors
- Keum, Se-Hoon (New Drug Research Center, Yuhan Research Institute) ;
- Lee, Bong-Yong (New Drug Research Center, Yuhan Research Institute)
- Published : 2003.04.01
Abstract
Human tumor necrosis factor-alpha (TNFa) is a key pro-inflammatory cytokine produced by activated monocytes and macrophage as a part of the self-defence machinery. TNF-a converting enzyme (TACE) is the metalloproteinase that processes the membrane bound precursor of TNFa to the soluble component. (omitted)
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