대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
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High Throughput Fluorogenic Assay for TNF-alpha Converting Enzyme(TACE) inhibitors

  • Keum, Se-Hoon (New Drug Research Center, Yuhan Research Institute) ;
  • Lee, Bong-Yong (New Drug Research Center, Yuhan Research Institute)
  • 발행 : 2003.04.01
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초록

Human tumor necrosis factor-alpha (TNFa) is a key pro-inflammatory cytokine produced by activated monocytes and macrophage as a part of the self-defence machinery. TNF-a converting enzyme (TACE) is the metalloproteinase that processes the membrane bound precursor of TNFa to the soluble component. (omitted)

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