Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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ent-Kaurane Diterpenoids from Croton tonkinensis Inhibit LPS-induced Transcription Factor NF-${\kappa}{B}$ Activation and NO Production

  • Giang, Phan-Minh (Faculty of Chemistry, Vietnam National University, Anticancer Agent Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Jin, Hui-Zi (Anticancer Agent Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Lee, Jung-Joon (Anticancer Agent Research Laboratory, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2003.04.01
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Abstract

Nuclear factor-${\kappa}{B}$ (NF-${\kappa}{B}$) belongs to a group of homodimers and heterodimers of Rel/NF-${\kappa}{B}$ proteins that bind to DNA target sites, where they directly regulate gene transcription. The activation of NF-${\kappa}{B}$ has been shown to mediate inflammation and suppress apoptosis. Activated NF-${\kappa}{B}$ has been found n various inflammatory diseases such as rheumatoid arthritis, Atherosclerosis, asthma, nflammatory bowel disease, and Helicobacter pylori-associated gastritis and associated with cancer, cachexia, diabetes, euthyroid sick syndrome, and AIDS. (omitted)

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