Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.111-113
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- 2003
New Insights in Arachidonate Cascade: Biochemical Characterization and Biological Significance of Three Distinct Prostaglandin E Synthases
Abstract
Biosynthsis of prostaglandin E2 (PGE2), the most common prostanoid with potent and diverse bio-activities, is regulated by three sequential enzymatic steps composed of phospholipase A2, cyclooxygenase (COX), and prostaglandin E synthase (PGES). Recently, three distinct PGESs have been identified; two of them are membrane-bound enzymes, mPGES-1 and mPGES-2, and the third one is a cytosolic enzyme, cPGES. (omitted)
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