Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10a
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- Pages.112-112
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- 2003
Effects of Berberine on Morphine-induced Neurotoxicity in Mice
- Jang, Choon-Gon (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University)
- Published : 2003.10.01
Abstract
Morphine is a potent analgesic and addictive substance. Morphine produces neurotoxicity such as rewarding effect, analgesic tolerance and physical dependence. It has been restricted to the use of morphine in patients because of these problems. The present study was investigated the effect of berberine on the neurotoxicity of morphine. Repeated administration of morphine produced conditioned place prefernece (CPP) and behavioral sensitization in mice. (omitted)
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