Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10a
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- Pages.89-89
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- 2003
Effective Generation of Lead Compounds by High Throughput Organic Synthesis: using Multipurpose Privileged Bezopyrans
- Gong, Young-Dae (The Center for High Throughput Synthesis Platform Technology, Korea Research Institute of Chemical Technology) ;
- Seo, Jin-soo (The Center for High Throughput Synthesis Platform Technology, Korea Research Institute of Chemical Technolog) ;
- Hwang, Jong-Yeon (The Center for High Throughput Synthesis Platform Technology, Korea Research Institute of Chemical Technolog) ;
- Park, Ji-Yeon (The Center for High Throughput Synthesis Platform Technology, Korea Research Institute of Chemical Technolog) ;
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Yoo, Sung-Eun
(The Center for High Throughput Synthesis Platform Technology, Korea Research Institute of Chemical Technology)
- Published : 2003.10.01
Abstract
Numerous lead compounds, based on multipurpose privileged structures, can be generated that address a variety of targets from a gene family of interest, irrespective of therapeutic area. Solid-phase organic synthesis has been emerged as a powerful technique in generating combinatorial libraries of small organic molecules useful for drug discovery. Heterocyclic compounds provide scaffolds on which pharmacophores can be arranged to yield potent and selective drugs and a variety of heterocycles have been synthesized on solid support. (omitted)
Keywords