Doxyclycline and Ciprofloxacin Treatment of Silk to Produce Novel Infection Resistance Biomaterials

  • Park, Hyung-Min (School of Textiles, Soongsil University) ;
  • Martin Bide (Department of Textiles, University of Rhode Island) ;
  • Matthew Phaneuf (Beth Israel Deaconess Medical Center, Harvard Medical School) ;
  • William Quist (Beth Israel Deaconess Medical Center, Harvard Medical School) ;
  • Frank Logerfo (Beth Israel Deaconess Medical Center, Harvard Medical School)
  • Published : 2003.10.01

Abstract

Two antibiotics, doxycycline (doxy) and ciprofloxacin (cipro) were applied under a variety of conditions to silk, and to silk that had previously been hydrolyzed. FTIR-ATR analyses indicated that the drastic increase in sorption of antibiotics by hydrolyzed silk was attributable to both chemical and conformational changes that occurred on hydrolysis. A high sorption of doxy by hydrolyzed silk did not necessarily give a more infection-resistant material as determined by a zone of inhibition test. Conversely, the same hydrolysis considerably increased both sorption of cipro and zone of inhibition of cipro-treated silk dyed at 65$^{\circ}C$ and 85$^{\circ}C$.

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