Proceedings of the Korean Fiber Society Conference (한국섬유공학회:학술대회논문집)

The Korean Fiber Society (한국섬유공학회)
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Culture of osteoblast on polyelectrolyte complexes (PECs) composed of polysaccharides

  • Teramoto, Akira (Department of Textile Science and Technology, Shinshu University) ;
  • Abe, Koji (Department of Textile Science and Technology, Shinshu University)
  • Published : 2003.10.01
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Abstract

Osteoblasts (MC3T3-E1) were cultured on polysaccharide type polyelectrolyte complex (PEC). The growth of the MC3T3-E1 on the PEC with carbxyl group (c-type) was slightly suppressed and exhibited aggregation morphology. On the other hand, cell growth on the PEC with sulfate group (s-type) was enhanced and the cell exhibited spreading form. Differentiation markers of osteoblast (ALPase activity, calcification, expression of osteocalsin) were enhanced and localized around cell aggregates on c-type PECs. These results suggest that PEC has the ability to control osteoblast proliferation and differentiation.

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