Proceedings of the Korean Society of Sericultural Science Conference (한국잠사학회:학술대회논문집)

Korean Society of Sericultural Science (한국잠사학회)
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Effects of Circular Type TGF-$\beta$1 Antisense Oligonucleotides on Anti-Thy-1 Glomerulonephritis

  • Han, Sang-Mi (Department of Sericulture and Entomology, National Institute of Agriculture and Technology) ;
  • Lee, Kwang-Gill (Department of Sericulture and Entomology, National Institute of Agriculture and Technolog) ;
  • Yeo, Joo-Hong (Department of Sericulture and Entomology, National Institute of Agriculture and Technolog) ;
  • Kweon, Hae-Yong (Department of Sericulture and Entomology, National Institute of Agriculture and Technolog) ;
  • Woo, Soon-Ok (Department of Sericulture and Entomology, National Institute of Agriculture and Technolog) ;
  • Park, Kwan-Kyu (Department of Pathology, College of Medicine, Keimyung University)
  • Published : 2003.10.01
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Abstract

Overproduction of transforming growth factor (TGF)-$\beta$l has been implicated in the pathogenesis of fibrotic diseases. TGF-$\beta$l plays a crucial role in the accumulation of extracellular matrix (ECM) in human and experimental glomerular diseases. However, it remains unclear whether inhibition of TGF- $\beta$l overproduction would suppress TGF- $\beta$l induced ECM accumulation. To inhibit the overproduction of TGF- $\beta$l in experimental glomerulonephritis induced by anti-Thy 1.1 antibody, we introduced antisense oligodeoxynucleotides (ODN) fur TGF- $\beta$l into the nephritic kidney by the HVJ-liposome-mediated gene transfer method. (omitted)

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