BDNF Promotes Neurite Growth and Survival of Antennal Lobe Neurons from the Silk Moth Bombyx mori in vitro

  • Kim, Jin-Hee (School of Life Sciences and Biotechnology, Korea University) ;
  • Sung, Dong-Kyung (School of Life Sciences and Biotechnology, Korea University) ;
  • Park, Chan-Woo (School of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Kang-Min (School of Life Sciences and Biotechnology, Korea University) ;
  • Park, Hun-Hee (School of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Hak-Ryul (School of Life Sciences and Biotechnology, Korea University) ;
  • Lee, Bong-Hee (School of Life Sciences and Biotechnology, Korea University)
  • Published : 2003.10.01

Abstract

Brain-derived neurotrophic factor (BDNF) induced a significant neurite extension of antennal lobe (AL) neurons from the silk moth Bombyx mori in culture on lamini/ concanavalin A-coated dishes, in comparison with smaller effect of 20-hydroxyecdy-sone (20-HE). But the effect fur neurite extension by 5-hydroxytryptamine (5-HT) could not be found. A significant increase in the number of new primary branches from the principal neurites of AL neurons was also shown in culture with BDNF and 5-HT, but not with 20-HE. (omitted)

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