Molecular Cloning, Expression and Functional Characterization of a Thioredoxin Peroxidase from the Silkworm Bombyx mori

  • Lee, Kwang-Sik (College of Natural Resources and Life Science, Dong-A University) ;
  • Lee, Sang-Mong (Department of Sericultural and Entomological Biology, Miryang National University) ;
  • Sohn, Hung-Dae (College of Natural Resources and Life Science, Dong-A University) ;
  • Jin, Byung-Rae (College of Natural Resources and Life Science, Dong-A University)
  • Published : 2003.10.01

Abstract

The thioredoxin peroxidase (TPx) is an antioxidant member of the peroxiredoxin family of enzymes. The TPx enzyme system has been implicated in the elimination of hydrogen peroxide and hydroxyl radicals generated during cellular processes. Such reactive molecules have been shown to cause damage to all major classes of biological macromolecules, including lipid, protein and DNA. Compared to mammalian peroxiredoxin genes, little is known about the insect TPx. (omitted)

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