Proceedings of the Korean Society of Veterinary Pathology Conference (한국수의병리학회:학술대회논문집)

Korean Society of Veterinary Pathology (한국수의병리학회)
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Evaluation of c-erbB2/neu Oncogene Status in Canine Mammary Tumors on Tissue Microarray

  • Kang, Jong-il (Choonghyun Animal Hospital) ;
  • Cho, Ho-seong (Dept.. of Vet. Pathol., College of Vet. Med., Chonnam National Univ) ;
  • A.W.M. Effendy (Dept.. of Vet. Pathol., College of Vet. Med., Chonnam National Univ) ;
  • Park, Nam-yong (Dept.. of Vet. Pathol., College of Vet. Med., Chonnam National Univ.)
  • Published : 2003.10.01
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Abstract

The c-erbB2/neu oncogene (alias HER2, NEU) encoding a tyrosine kinase receptor protein, the overexpression of which correlates with a more rapid progression and a worse prognosis in human breast cancer [1]. Otherwise, this gene is still poorly investigated in veterinary oncology [2,3]. To gain insight into the patterns of c-erbB2/neu status in canine mammary tumor, we constructed one such mammary tumor tissue microarray (TMA) from 60 tumors from our lab. This enabled the amplification of c-erbB2/neu oncogene of all 60 tumors to be simultaneously analyzed by chromogenic in situ hybridization (CISH). The aim of this study was to evaluate status of c-erbB2/neu oncogene in canine mammary tumors and to correlate this status with the differentiation grade of neoplasm. (omitted)

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